If I had to choose only 1 firearm to take into the wilderness, it wouldn't be a .45ACP in any platform. While it's a dandy manstopper, it's very marginal as a hunting round for anything much bigger than a man. It is my daily defensive carry (in Glock 30 or G21 format).
OTOH, a .41mag is close to the ideal - except very hard to find ammo these days. A .44mag is really too much for most.
But, a 10mm is pretty good all around - comes in auto (there was even a S&W variant chambered for it for a brief time), good stopper, fast reloads. Or, go cowboy and carry a wheelgun in .45LC and a similarly chambered lever action.