Over the years I've used 22-250 (first deer rifle as a kid/teen/college), 30-30 (336 Marlin lever-action), 308 (TL3 Custom), 300BLK (9" SBR), .257 Weatherby Magnum (Weatherby MkV), 6.5 Creedmoor (Bergara) but for the past two seasons I have been sticking with a custom Zermatt TL3 shorty 308 for pretty much any medium size game here in Texas. The 300BLK still see's pig patrol and the 30-30 makes a showing every season for nostalgias sake. The 22-250 and 257 will likely end up going to nephews for their first deer rifles.