Nope, wouldn't make sense to only offer it with 2WD. Although payload might be a little higher with 2WD, they definitely offer it in 4WD. You can do a build on Ford.com, which should show you all the configurations available.
-
Here is one. Supercrew, 4x4, V8, XL, 36 gal tank, 3.73 e-locker...