Wayne Gerdes and colleagues at CleanMPG.com have driven a stock Ram 1500 Ecodiesel 1000 miles on a single tank of fuel. That's a little better than 38 mpg. The team drove from Texas to Indiana.
http://green.autoblog.com/2014/05/09/hypermiling-ram-1500-ecodiesel-38-mpg/
The article linked above has details of the techniques they used. Apart from trying to trick the truck's 8 speed transmission into remaining in high gear as long as possible, the top tip was to hold speed a little below the posted limit on any given road.
The team drove a stock pickup, carrying four people, their luggage, and a competition-winning mpg vehicle in the truck bed. Photos accompanying the article show that the competition vehicle was too long to fit in the bed, so they drove with the tailgate down. This may have helped increase mpg, too.