Yaesu FT-8800R has about the best receive I've seen in a mobile ham radio. Excellent sensitivity, and very little in the way of intermod, even while receiving outside the ham band right in the middle of the Los Angeles area.
The 8800 certainly isn't the cheapest radio available, but I think it's well worth it's cost. Has cross-band repeat if you ever need it (good for using your handheld as a remote mic away from your vehicle)
Good sounding transmit seems to be almost a given with any radio (some maybe a little tinnier than others, but none seem to be muffly or otherwise difficult to understand on the air).
Someone else may be able to comment better on handhelds (been out of the loop for awhile).
I do know there is the Baofeng UV-5R if you want "budget handheld". Heard 'em on the air... A little thin sounding, but again, pretty clear audio. No idea what their receive is like (I probably wouldn't expect a whole lot).
I have an older FT-50R that's been brutally durable (dropped into shallow water, dropped from an ATV at 30 MPH, left in the hot direct summer sun in a black car, etc.).
Seems the norm in handhelds is good receive sensitivity, but mediocre intermod rejection.